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session7
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Lecture and Lab
Lecture notes
Lecture notes PDF
Lab materials
Lecture
Learning objectives
Define proportional hazards
Perform and interpret Cox proportional hazards regression
Define time-dependent covariates and their use
Identify the differences between parametric and semi-parametric survival models
Identify situations when a parametric survival model might be useful
Outline
Review of survival and hazard functions
The Cox proportional hazards model
interpretation and inference
what are proportional hazards
when hazards aren’t proportional
Parametric vs semi-parametric survival models
Vittinghoff sections 6.1-6.2, 6.4
Lab
Learning Objectives
Fit a Cox proportional hazard model
Create a stratified Kaplan-Meier plot
Fit exponential and Weibull accelerated failure time models
Fit a model using strata and a time-dependent covariate
Create a DAG using dagitty
Exercises
Fit a Cox proportional hazard model to the Leukemia 6 MP clinical trial dataset
Create a stratified Kaplan-Meier plot
Fit exponential and Weibull accelerated failure time (AFT) models
Fit a stratified coxph model with a time-dependent covariate using an example from ?coxph
Draw a DAG starting from dagitty.net and re-create it in R
Links
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License
Full license
CC BY 4.0
Citation
Citing session7
Developers
Levi Waldron
Author, maintainer
Dev status